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KMID : 0378019900330040113
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New Medical Journal
1990 Volume.33 No. 4 p.113 ~ p.117
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Antihtpertensive Effect of angiotensin Converting Enzyme Inhibitor(Capril^(®)) in Mild to Moderate Hypertensive Patients
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Abstract
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We investigated the antihypertensive effect of the low dose of angiotensin converting enzyme inhibitor, Capril® in 22 mild-to-moderate hypertensive patients. Initially, a low dose Capril, i.e., 12.5 mg twice a day was administered, and then the dose was increased to a maximum of 25 mg twice a day depending upon the response. In patients not responding to the dose of Capril® 50 mg / day, hydrochlorthiazide 25 mg daily was added. The end point viz. diastolic blood pressure of 90 mmHg or less was reached in 12 (54.5%) of 22 patients is with a low dose (25-50 mg / day) of Capril® and in another 6 patients after addition of diuretic. The blood pressure was normalized in 81.8% of 22 hypetrensive patients with a low dose Capril® and a diuretic combination. No significant changes were produced in serum electrolytes, lipid, creatinine, FBS, liver function and blood count. There was no increase in protei- nuria. Cough developed in 5 patients out of 22 patients and Capril® administration was discontinued in 2 of those 5 patients. In another one patient, Capril® was withdrawn because - of generalized muscle aching with low back pain and shoulder pain. Gastro-intestinal disco - fort and mild dizziness occurred in one patient. respectively.
We conclude that Capril® is effective as initial therapy in mild to moderate hypertensive patients.
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